High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues
نویسندگان
چکیده
منابع مشابه
High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues
Eukaryotic transmembrane helical (TMH) proteins perform a wide diversity of critical cellular functions, but remain structurally largely uncharacterized and their high-resolution structure prediction is currently hindered by the lack of close structural homologues. To address this problem, we present a novel and generic method for accurately modeling large TMH protein structures from distant ho...
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The prediction and design at the atomic level of membrane protein structures and interactions is a critical but unsolved challenge. To address this problem, we have developed an all-atom physical model that describes intraprotein and protein-solvent interactions in the membrane environment. We evaluated the ability of the model to recapitulate the energetics and structural specificities of poly...
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Recently, methods for the analysis and design of water-soluble, oligomeric bundles of alpha helices, including coiled coils, have reached a high level of sophistication. These same methods may now be applied to transmembrane helical bundles. Studies of the transmembrane domains of glycophorin, phospholamban, and the M2 protein from influenza A virus exemplify this general approach.
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Transmembrane (TM) proteins comprise some 15% to 30% of the proteome, and the number of reported 3D structures has grown rapidly over the past decade. Nevertheless, owing to technical difficulties, the vast majority of TM protein structures are yet to be determined. Computational modeling techniques can be used to provide the essential structural data needed to shed light on structure-function ...
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The propensity to misfold and self-assemble into stable aggregates is increasingly being recognized as a common feature of protein molecules. Our understanding of this phenomenon and of its links with human disease has improved substantially over the past two decades. Studies thus far, however, have been almost exclusively focused on cytosolic proteins, resulting in a lack of detailed informati...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2014
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003636